SKN on HIgh Risk Travel List, Dogs Detect Covid Better Than Tests, Pfizer Ups Production, World Stats, More

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The Centers for Disease Control and Prevention (CDC) has added four destinations to its list of “high-risk” travel locations regarding COVID-19 statistics.

Guyana, Mongolia, Namibia and St. Kitts and Nevis were all deemed a Level 3 travel risk on Monday, according to the CDC. They were previously categorized at Level 2, or “moderate” risk.

“Make sure you are up to date with your COVID-19 vaccines before traveling to these destinations. If you are not up to date with your COVID-19 vaccines, avoid travel to these destinations,” the CDC warned about Level 3 locations.

To be considered a Level 3 or high-risk destination, countries must have more than 100 new COVID-19 cases per 100,000 residents over the past 28 days.

Level 4 is known as “Special Circumstances/Do Not Travel.” No locations are currently on that list.

In April, the agency removed all destinations from the Level 4 risk category, saying it would reserve “Level 4” warnings “for special circumstances, such as rapidly escalating case trajectory or extremely high case counts, emergence of a new variant of concern, or healthcare infrastructure collapse.”

“With this new configuration, travelers will have a more actionable alert for when they should not travel to a certain destination (Level 4), regardless of vaccination status, until we have a clearer understanding of the COVID-19 situation at that destination,” the statement added.

In the U.S., cases are on a slightly upward trend, with a national daily case average of more than 98,000, the CDC’s data showed as of Monday.

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FDA panel gives nod to Novavax COVID-19 shot 

© Getty

An outside advisory panel voted overwhelmingly to recommend the Food and Drug Administration (FDA) authorize a COVID-19 vaccine made by Novavax for use in adults, a move that could lead to adding a fourth vaccine to the U.S. arsenal.

The FDA’s vaccine advisory panel voted 21-0, with one abstention. The FDA does not have to follow the panel’s recommendation, though it often does.

  • Novavax’s two-dose vaccine was about 90 percent effective at preventing mild, moderate and severe COVID-19 during clinical trials.
  • But critically, the trials were conducted before the omicron variant and panel members expressed concern about whether the efficacy would hold up against the current variants.

Reaching vaccine holdouts: Novavax’s vaccine could appeal to people who have been reluctant to receive one of the mRNA vaccines, as it was manufactured using a fundamentally different process.

But winning over even a small number of eligible people who haven’t yet been vaccinated could be a difficult task and it’s not clear how much success the company will find. The U.S. is not short on doses from any of the Pfizer-BioNTech or Moderna vaccines that have been available for more than a year.

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Trained Dogs Better than Covid Test is Detecting the Virus in People

Trained dogs were better at detecting positive Covid cases than a rapid antigen test, a study found.

By Aria Bendix

The Hill

Questions about whether dogs can sniff out Covid — and how well — have intrigued researchers since early in the pandemic.

A study published Wednesday in the journal Plos One offers further evidence that dogs can indeed be trained to detect Covid. The dogs tested in the research accurately identified 97 percent of positive cases after sniffing human sweat samples. That made them more sensitive than some rapid antigen tests.

The samples were collected at community centers in Paris from a mix of symptomatic and asymptomatic cases, as well as healthy people without Covid. The researchers found the dogs to be especially good at detecting asymptomatic infections, with a sensitivity nearing 100 percent.

Previous studies have also highlighted this canine skill: Researchers in Florida last year found that that dogs could predict positive Covid tests with 73 to 93 percent accuracy after a month of training. In a U.K. study, dogs accurately pinpointed 82 to 94 percent of positive cases.

The new study was conducted in early 2021, so the dogs were identifying the original coronavirus. Dominique Grandjean, one of the study’s authors and a professor at the Alfort National Veterinary School in France, said he’s now examining how well dogs pick up on variants.

Grandjean said his findings suggest that dogs might be useful for detecting Covid in airports, nursing homes, schools, or sporting events. Already, dogs have helped sniff out Covid at airports in Saudi Arabia, Finland and the United Arab Emirates.

“That’s one of the big challenges — to have the dog learn to translate from a sample to an entire human being, which is a much more complex odor,” she said.

For anyone hoping to train their own pet to sniff out Covid, Otto had some advice: “Don’t try this at home.”

Dogs “only need a few molecules” to identify a positive case, Grandjean said.

But Dr. Cynthia Otto, director of the Penn Vet Working Dog Center at the University of Pennsylvania, said it’s difficult to train dogs to detect Covid in the real world.

“The ideal — and I would consider it the Holy Grail — is that the dog is just standing there, a person walks by, and they say, ‘Yes, no, yes, no, yes, no,'” Otto said. “That eventually could be done, but making sure it’s done with all the proper controls and quality assurances and safety — it’s a big step. I haven’t seen anyone who has proposed how to make that transition in a way that’s scientific and safe.”

A less invasive way to detect Covid?

For the new study, researchers trained five dogs by rewarding them with toys for detecting a positive Covid sample.

The dogs then sniffed 335 sweat samples, 109 of which were positive on PCR lab tests. Each sample was placed in a tiny box behind a cone, with the cones lined up in rows of 10. If a dog thought it detected a positive case, it would sit down.

Grandjean estimated that it took just 15 seconds for the dogs to analyze 20 Covid samples. When it came to categorizing negative samples — known as specificity in testing — the dogs were slightly less accurate. They identified 91 percent of the Covid-free samples correctly, meaning they gave some false positives.

Still, Grandjean said, dogs offer a couple advantages for Covid testing: They’re less invasive than a nasal or throat swab and provide more immediate results (not counting the training time).

Both Grandjean and Otto also said that dogs have demonstrated an ability to detect infections earlier in the course of a person’s illness than PCR tests. In many cases, Grandjean hypothesized, someone who tests negative on a PCR but positive according to a dog’s assessment will likely test positive on a PCR two days later.

Otto said dogs might therefore be a useful prescreening tool to flag potential cases that could later be confirmed in a lab.

‘Don’t try this at home’

Before the pandemic, Grandjean was studying whether dogs could sniff out colon cancer. In 2020, he switched his focus to Covid. His research involves labradors, German shepherds and Belgian shepherds, and he previously found that dogs can detect Covid from sniffing a person’s mask.

Part of the reason dogs can do that, Grandjean said, is that they have an organ in their noses called the Jacobson’s organ, which helps them identify smells that seem odorless to humans. That’s how dogs can pick up on coronavirus proteins.

Dogs can also smell volatile organic compounds, or gases found in exhaled air, saliva or sweat. Grandjean said Covid has certain volatile organic compounds that dogs detect, but “we don’t know exactly what they are chemically.”

Grandjean said any breed could detect Covid if it enjoys playing and doesn’t have a shortened snout. Other animals, like cats, have similarly strong senses of smell, he added, but dogs are easier to train.

However, the training process is highly technical, Otto said. Outside odors can interfere, and it’s not always easy to tell if dogs are searching for the right scent. Dogs are taught using positive reinforcement; similar strategies are used to train them to find termites or sniff out drugs. But of course, not all dogs like the same rewards, Otto said.

“For some dogs, a ball might be the absolute best thing in the world, where another dog might think that a tug toy or a squeaky rabbit is the best thing,” she said. Other dogs, meanwhile, just “get really bored with it.”

What’s more, Otto added, a dog’s ability to detect Covid in a sweat sample or piece of clothing doesn’t necessarily mean it will be able to do so when facing a real person.

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Pfizer pledges $120M to boost COVID pill production

© AP

Pfizer announced Monday that it is investing $120 million to boost production of its COVID-19 treatment pills in the United States.

What they’re saying: The move will create more than 250 jobs at its plant in Kalamazoo, Mich., the company said, as it looks to increase production of Paxlovid.

The investment “will allow Pfizer to increase supply by an additional 4 million packs of Paxlovid, allowing us to meet global demand and help increase overall access,” said Pfizer spokeswoman Julia Cohen.

  • Increasing availability and use of Paxlovid has been a primary goal of the Biden administration. Health officials have acknowledged that in the early days after it was authorized in December, supply of the medication was limited and many doctors were reluctant to prescribe it for all but the highest-risk patients.
  • Paxlovid is seen as a key part of making COVID-19 more manageable, given that the treatment has been shown to reduce the risk of hospitalization or death by around 90 percent.

WORLD COVID STATS

Coronavirus Cases:

536,696,747

Deaths:

6,323,652

Recovered:

507,857,194

 

 

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